Open AccessDiabetes mellitus and risk of cancer in T akayama: A population‐based prospective cohort study in J apan
Author(s) -
Nakamura Kozue,
Wada Keiko,
Tamai Yuya,
Tsuji Michiko,
Kawachi Toshiaki,
Hori Akihiro,
Takeyama Naoharu,
Tanabashi Shinobu,
Matsushita Shogen,
Tokimitsu Naoki,
Nagata Chisato
Publication year - 2013
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12235
Subject(s) - medicine , hazard ratio , prospective cohort study , diabetes mellitus , cancer , proportional hazards model , cohort , population , cohort study , incidence (geometry) , confidence interval , gastroenterology , endocrinology , environmental health , physics , optics
Diabetes mellitus ( DM ) has been reported to be associated with an increased risk of site‐specific cancers; however, few studies have assessed associations of DM with both total and site‐specific cancers in J apan. We examined the association of a history of DM with cancer incidence in a population‐based prospective cohort study in Japan. A total of 14 173 men and 16 547 women over 35 years old, who completed a self‐administered baseline questionnaire in 1992, were followed up for cancer incidence from S eptember 1992 to M arch 2008. At baseline, 6.3% men and 2.9% women had a history of diabetes. A total of 1974 men and 1514 women were identified as newly diagnosed with cancer. Hazard ratios ( HR ) and 95% confidence intervals ( CI ) were determined using C ox proportional hazards models. After controlling for potential confounders, men with DM had a modest risk increase of total cancer occurrence compared with those without DM ( HR , 1.09; 95% CI , 0.93–1.29). Increased risk of cancer of the liver ( HR , 2.18; 95% CI , 1.27–3.74), bile duct ( HR , 2.17; 95% CI , 1.01–4.66), and larynx ( HR , 3.61; 95% CI , 1.16–11.2) in diabetic men were observed. In women, significant increased risk of total cancer ( HR , 1.35; 95% CI , 1.06–1.73) and stomach cancer ( HR , 2.15; 95% CI , 1.30–3.54) were observed among diabetic subjects. These data suggest that people with DM may be at increased risk of both total and some site‐specific cancers.