Open AccessEffects of radiation on the incidence of prostate cancer among Nagasaki atomic bomb survivors
Author(s) -
Kondo Hisayoshi,
Soda Midori,
Mine Mariko,
Yokota Kenichi
Publication year - 2013
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12234
Subject(s) - prostate cancer , medicine , incidence (geometry) , relative risk , cancer , prostate , confidence interval , demography , oncology , physics , sociology , optics
Atomic bomb survivors have been reported to have an increased risk of some cancers, especially leukemia. However, the risk of prostate cancer in atomic bomb survivors is not known to have been examined previously. This study examined the association between atomic bomb radiation and the incidence of prostate cancer among male N agasaki atomic bomb survivors. The subjects were classified by distance from the hypocenter into a proximal group (<2 km), a distal group (≥2 km), and an early entrance group (those who entered the region <2 km from the hypocenter within 2 weeks after the explosion). Between 1996 and 2009, 631 new cases of prostate cancer were identified among approximately 18 400 male Nagasaki atomic bomb survivors who were alive in 1996. The Cox proportional hazard model was used to estimate the risk of prostate cancer development, with adjustment for age at atomic bomb explosion, attained age, smoking status, and alcohol consumption. Compared with the distal group, the proximal group had significant increased risks of total, localized, and high‐grade prostate cancer (relative risk and 95% confidence interval: 1.51 [1.21–1.89]; 1.80 [1.26–2.57]; and 1.88 [1.20–2.94], respectively). This report is the first known to reveal a significant relationship between atomic bomb radiation and prostate cancer.