Open Access
Locoregional recurrence of pT 3N0M0 breast cancer after mastectomy is not higher than that of pT 1‐2N0M0: A n analysis for radiotherapy
Author(s) -
Sun JiaYuan,
Wu SanGang,
Li Sheng,
Li FengYan,
Chen WenFen,
Lin Qin,
He ZhenYu
Publication year - 2013
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12130
Subject(s) - medicine , breast cancer , radiation therapy , mastectomy , univariate analysis , oncology , multivariate analysis , metastasis , cancer , breast conserving surgery , gastroenterology
The purpose of this study was to investigate the value of post‐operative radiotherapy in the treatment of p T 3 N 0 M 0 breast cancer after mastectomy. We analyzed the clinical data of 1390 patients with p T 1‐3 N 0 M 0 breast cancer who were admitted and treated from 1998 to 2007 at the S un Y at‐sen U niversity C ancer C enter. All patients underwent mastectomy and did not receive radiotherapy. The locoregional recurrence‐free survival, distant metastasis‐free survival and overall survival of different T stages of breast cancer were compared. The median follow‐up duration was 72 months. The 10‐year locoregional recurrence‐free survival patients with p T 1 N 0, p T 2 N 0 and p T 3 N 0 breast cancers were 95.3, 91.9 and 93.6%, respectively ( χ 2 = 2.550, P = 0.279). The 10‐year distant metastasis‐free survival rates of patients with p T 1 N 0, p T 2 N 0 and p T 3N0 breast cancers were 88.1%, 81.0% and 78.4%, respectively ( χ 2 = 8.254, P = 0.016). The 10‐year overall survival rates of patients with p T 1 N 0, p T 2 N 0 and pT 3 N 0 breast cancers were 91.9%, 83.5% and 73.0%, respectively ( χ 2 = 12.403, P = 0.002). Univariate analyses failed to identify any prognostic factors for locoregional recurrence in pT 3 N 0 patients. Multivariate analysis showed that the T stage had no effect on locoregional recurrence. The locoregional recurrence rate in patients with pT 3 N 0 M 0 breast cancer who underwent mastectomy and did not receive postoperative radiotherapy was not higher than that in patients with pT 1‐2 N 0 M 0 breast cancer who received the same treatment, suggesting that routine adjuvant post‐operative radiotherapy should not be recommended in this patient population.