Open AccessSuppression of KIF 14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome
Author(s) -
Yang Tao,
Zhang XianBo,
Zheng ZhiMin
Publication year - 2013
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12128
Subject(s) - carcinogenesis , hepatocellular carcinoma , biology , downregulation and upregulation , cancer research , mitosis , cell growth , liver cancer , cancer , apoptosis , cytokinesis , kinase , medicine , cell , microbiology and biotechnology , cell division , genetics , gene
The mitotic kinesin superfamily protein KIF 14 is essential for cytokinesis and chromosome segregation and increased KIF 14 expression is related to a variety of human cancers. In this study, we investigate KIF 14 expression in association with clinical variables and the role of KIF 14 during tumorigenesis. We found that KIF 14 is overexpressed in most primary hepatocellular carcinoma ( HCC ) tissues compared with the adjacent normal liver tissues and KIF 14 overexpression is associated with tumor grade ( P = 0.002), stage ( P = 0.013) and poor survival ( P < 0.001). Downregulation of KIF 14 decreased the capacity of proliferation both in vitro and in vivo . Furthermore, suppression of KIF 14 not only decreases cancer cell migration but also induces apoptosis of cells with inactivation of the phosphatidylinositol 3‐kinase‐Akt signaling pathway. Therefore, our current study indicates that KIF 14 promotes HCC carcinogenesis and may serve as a potential therapeutic target for human HCC .