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Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to peri‐implantation embryos
Author(s) -
Reza Abu Musa Md Talimur,
Choi YunJung,
Han Sung Gu,
Song Hyuk,
Park Chankyu,
Hong Kwonho,
Kim JinHoi
Publication year - 2019
Publication title -
biological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.993
H-Index - 165
eISSN - 1469-185X
pISSN - 1464-7931
DOI - 10.1111/brv.12459
Subject(s) - biology , microrna , sterility , germ cell , reproduction , context (archaeology) , embryo , human reproduction , biogenesis , sexual reproduction , microbiology and biotechnology , gene , genetics , paleontology
MicroRNAs (miRNAs) are active regulators of numerous biological and physiological processes including most of the events of mammalian reproduction. Understanding the biological functions of miRNAs in the context of mammalian reproduction will allow a better and comparative understanding of fertility and sterility in male and female mammals. Herein, we summarize recent progress in miRNA‐mediated regulation of mammalian reproduction and highlight the significance of miRNAs in different aspects of mammalian reproduction including the biogenesis of germ cells, the functionality of reproductive organs, and the development of early embryos. Furthermore, we focus on the gene expression regulatory feedback loops involving hormones and miRNA expression to increase our understanding of germ cell commitment and the functioning of reproductive organs. Finally, we discuss the influence of miRNAs on male and female reproductive failure, and provide perspectives for future studies on this topic.