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Transcription factors and cognate signalling cascades in the regulation of autophagy
Author(s) -
Chandra Vemika,
Bhagyaraj Ella,
Parkesh Raman,
Gupta Pawan
Publication year - 2016
Publication title -
biological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.993
H-Index - 165
eISSN - 1469-185X
pISSN - 1464-7931
DOI - 10.1111/brv.12177
Subject(s) - autophagy , effector , signalling , transcription factor , microbiology and biotechnology , biology , hedgehog signaling pathway , transcription (linguistics) , signal transduction , gene , genetics , apoptosis , linguistics , philosophy
ABSTRACT Autophagy is a process that maintains the equilibrium between biosynthesis and the recycling of cellular constituents; it is critical for avoiding the pathophysiology that results from imbalance in cellular homeostasis. Recent reports indicate the need for the design of high‐throughput screening assays to identify targets and small molecules for autophagy modulation. For such screening, however, a better understanding of the regulation of autophagy is essential. In addition to regulation by various signalling cascades, regulation of gene expression by transcription factors is also critical. This review focuses on the various transcription factors as well as the corresponding signalling molecules that act together to translate the stimuli to effector molecules that up‐ or downregulate autophagy. This review rationalizes the importance of these transcription factors functioning in tandem with cognate signalling molecules and their interfaces as possible therapeutic targets for more specific pharmacological interventions.