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Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
Author(s) -
Gusareva Elena S.,
Kurey Iryna,
Grekov Igor,
Lipoldová Marie
Publication year - 2014
Publication title -
biological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.993
H-Index - 165
eISSN - 1469-185X
pISSN - 1464-7931
DOI - 10.1111/brv.12059
Subject(s) - immunology , immunoglobulin e , biology , disease , immune system , antibody , pathogenesis , pathological , medicine , pathology
Immunoglobulin E ( IgE ) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti‐tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody.