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Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments
Author(s) -
Zobdeh Farzin,
Kraiem Aziza,
Attwood Misty M.,
Chubarev Vladimir N.,
Tarasov Vadim V.,
Schiöth Helgi B.,
Mwinyi Jessica
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15657
Subject(s) - migraine , medicine , clinical trial , drug , drug development , intensive care medicine , chronic migraine , food and drug administration , migraine treatment , disease , pharmacotherapy , alternative medicine , pharmacology , psychiatry , pathology
Migraine is the sixth most prevalent disease globally, a major cause of disability, and it imposes an enormous personal and socio‐economic burden. Migraine treatment is often limited by insufficient therapy response, leading to the need for individually adjusted treatment. In this review, we analyse historical and current pharmaceutical development approaches in acute and chronic migraine based on a comprehensive and systematic analysis of Food and Drug Administration (FDA)‐approved drugs and those under investigation. The development of migraine therapeutics has significantly intensified during the last 3 years, as shown by our analysis of the trends of drug development between 1970 and 2020. The spectrum of drug targets has expanded considerably, which has been accompanied by an increase in the number of specialised clinical trials. This review highlights the mechanistic implications of FDA‐approved and currently investigated drugs and discusses current and future therapeutic options based on identified drug classes of interest.