Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects | Zendy

LópezCano Marc | Zendy; Font Joan | Zendy; Aso Ester | Zendy; Sahlholm Kristoffer | Zendy; Cabré Gisela | Zendy; Giraldo Jesús | Zendy; De Koninck Yves | Zendy; Hernando Jordi | Zendy; Llebaria Amadeu | Zendy; FernándezDueñas Víctor | Zendy; Ciruela Francisco | Zendy

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Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects

Author(s) -

LópezCano Marc,

Font Joan,

Aso Ester,

Sahlholm Kristoffer,

Cabré Gisela,

Giraldo Jesús,

De Koninck Yves,

Hernando Jordi,

Llebaria Amadeu,

FernándezDueñas Víctor,

Ciruela Francisco

Publication year - 2023

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.15645

Subject(s) - morphine , opioid , adverse effect , anesthesia , medicine , pharmacology , receptor

Opioid-based drugs are the gold standard medicines for pain relief. However, tolerance and several side effects (i.e. constipation and dependence) may occur upon chronic opioid administration. Photopharmacology is a promising approach to improve the benefit/risk profiles of these drugs. Thus, opioids can be locally activated with high spatiotemporal resolution, potentially minimizing systemic-mediated adverse effects. Here, we aimed at developing a morphine photo-derivative (photocaged morphine), which can be activated upon light irradiation both in vitro and in vivo.

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