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Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects
Author(s) -
LópezCano Marc,
Font Joan,
Aso Ester,
Sahlholm Kristoffer,
Cabré Gisela,
Giraldo Jesús,
De Koninck Yves,
Hernando Jordi,
Llebaria Amadeu,
FernándezDueñas Víctor,
Ciruela Francisco
Publication year - 2023
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15645
Subject(s) - opioid , morphine , pharmacology , medicine , (+) naloxone , nociception , in vivo , analgesic , adverse effect , drug tolerance , anesthesia , constipation , receptor , biology , microbiology and biotechnology
Opioid-based drugs are the gold standard medicines for pain relief. However, tolerance and several side effects (i.e. constipation and dependence) may occur upon chronic opioid administration. Photopharmacology is a promising approach to improve the benefit/risk profiles of these drugs. Thus, opioids can be locally activated with high spatiotemporal resolution, potentially minimizing systemic-mediated adverse effects. Here, we aimed at developing a morphine photo-derivative (photocaged morphine), which can be activated upon light irradiation both in vitro and in vivo.