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Short‐chain fatty acids and bile acids in human faeces are associated with the intestinal cholesterol conversion status
Author(s) -
Matysik Silke,
Krautbauer Sabrina,
Liebisch Gerhard,
Schött HansFrieder,
Kjølbæk Louise,
Astrup Arne,
Blachier Francois,
Beaumont Martin,
Nieuwdorp Max,
Hartstra Annick,
Rampelli Simone,
Pagotto Uberto,
Iozzo Patricia
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15440
Subject(s) - coprostanol , sterol , feces , bile acid , cholesterol , biology , short chain fatty acid , context (archaeology) , biochemistry , microbiome , gut flora , fgf19 , physiology , food science , microbiology and biotechnology , bioinformatics , butyrate , paleontology , receptor , fermentation , fibroblast growth factor
The analysis of human faecal metabolites can provide an insight into metabolic interactions between gut microbiota and the host organism. The creation of metabolic profiles in faeces has received little attention until now, and reference values, especially in the context of dietary and therapeutic interventions, are missing. Exposure to xenobiotics significantly affects the physiology of the microbiome, and microbiota manipulation and short-chain fatty acid administration have been proposed as treatment targets for several diseases. The aim of the present study is to give concomitant concentration ranges of faecal sterol species, bile acids and short-chain fatty acids, based on a large cohort.