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Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis
Author(s) -
Olona Antoni,
Hateley Charlotte,
Guerrero Ana,
Ko JeongHun,
Johnson Michael R.,
Anand Paras K.,
Thomas David,
Gil Jesus,
Behmoaras Jacques
Publication year - 2022
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15423
Subject(s) - adipose tissue , cytotoxicity , pyroptosis , monocyte , adipose tissue macrophages , white adipose tissue , stromal vascular fraction , endocrinology , ouabain , medicine , chemistry , programmed cell death , pharmacology , biology , apoptosis , biochemistry , in vitro , organic chemistry , sodium
Cardiac glycosides inhibit Na + /K + -ATPase and are used to treat heart failure and arrhythmias. They can induce inflammasome activation and pyroptosis in macrophages, suggesting cytotoxicity, which remains to be elucidated in human tissues.