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Beneficial effects of a combination of natural product activators of autophagy on endothelial cells and platelets
Author(s) -
Carnevale Roberto,
Nocella Cristina,
Schiavon Sonia,
Cammisotto Vittoria,
Cotugno Maria,
Forte Maurizio,
Valenti Valentina,
Marchitti Simona,
Vecchio Daniele,
Biondi Zoccai Giuseppe,
Rubattu Speranza,
Martinelli Ombretta,
Pignatelli Pasquale,
Violi Francesco,
Volpe Massimo,
Versaci Francesco,
Frati Luigi,
Frati Giacomo,
Sciarretta Sebastiano
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15399
Subject(s) - autophagy , oxidative stress , platelet , umbilical vein , pharmacology , platelet activation , nitric oxide , chemistry , spermidine , angiogenesis , trehalose , endothelial stem cell , endothelial dysfunction , biochemistry , medicine , in vitro , apoptosis , enzyme
Oxidative stress and insufficient autophagy activity are associated with inflammatory processes and are common features of many cardiovascular diseases (CVDs). We investigated if a combination of natural activators of autophagy could modulate oxidative stress, platelet aggregation and endothelial cell survival and function in response to stress.