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The ratio of ursodeoxycholyltaurine to 7‐oxolithocholyltaurine serves as a biomarker of decreased 11β‐hydroxysteroid dehydrogenase 1 activity in mouse
Author(s) -
Weingartner Michael,
Stücheli Simon,
Kratschmar Denise V.,
Birk Julia,
Klusonova Petra,
Chapman Karen E.,
Lavery Gareth G.,
Odermatt Alex
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15367
Subject(s) - carbenoxolone , 11β hydroxysteroid dehydrogenase type 1 , endocrinology , medicine , dehydrogenase , cortisone , chemistry , enzyme , ursodeoxycholic acid , enzyme assay , biology , biochemistry , intracellular , gap junction
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) regulates tissue-specific glucocorticoid metabolism and its impaired expression and activity are associated with major diseases. Pharmacological inhibition of 11β-HSD1 is considered a promising therapeutic strategy. This study investigated whether alternative 7-oxo bile acid substrates of 11β-HSD1 or the ratios to their 7-hydroxy products can serve as biomarkers for decreased enzymatic activity.