The ratio of ursodeoxycholyltaurine to 7‐oxolithocholyltaurine serves as a biomarker of decreased 11β‐hydroxysteroid dehydrogenase 1 activity in mouse | Zendy

Weingartner Michael | Zendy; Stücheli Simon | Zendy; Kratschmar Denise V. | Zendy; Birk Julia | Zendy; Klusonova Petra | Zendy; Chapman Karen E. | Zendy; Lavery Gareth G. | Zendy; Odermatt Alex | Zendy

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The ratio of ursodeoxycholyltaurine to 7‐oxolithocholyltaurine serves as a biomarker of decreased 11β‐hydroxysteroid dehydrogenase 1 activity in mouse

Author(s) -

Weingartner Michael,

Stücheli Simon,

Kratschmar Denise V.,

Birk Julia,

Klusonova Petra,

Chapman Karen E.,

Lavery Gareth G.,

Odermatt Alex

Publication year - 2021

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.15367

Subject(s) - carbenoxolone , 11β hydroxysteroid dehydrogenase type 1 , endocrinology , medicine , dehydrogenase , cortisone , chemistry , enzyme , ursodeoxycholic acid , enzyme assay , biology , biochemistry , intracellular , gap junction

11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) regulates tissue-specific glucocorticoid metabolism and its impaired expression and activity are associated with major diseases. Pharmacological inhibition of 11β-HSD1 is considered a promising therapeutic strategy. This study investigated whether alternative 7-oxo bile acid substrates of 11β-HSD1 or the ratios to their 7-hydroxy products can serve as biomarkers for decreased enzymatic activity.

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