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Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors
Author(s) -
Ménégaut Louise,
Jalil Antoine,
Pilot Thomas,
Dongen Kevin,
Crespy Valentin,
Steinmetz Eric,
Pais de Barros Jean Paul,
Geissler Audrey,
Le Goff Wilfried,
Venteclef Nicolas,
Lagrost Laurent,
Gautier Thomas,
Thomas Charles,
Masson David
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15358
Subject(s) - oxysterol , liver x receptor , glycolysis , biology , hexokinase , atheroma , receptor , microbiology and biotechnology , medicine , endocrinology , nuclear receptor , biochemistry , cholesterol , metabolism , gene , transcription factor
Subset of macrophages within the atheroma plaque displays a high glucose uptake activity. Nevertheless, the molecular mechanisms and the pathophysiological significance of this high glucose need remain unclear. While the role for hypoxia and hypoxia inducible factor 1α has been demonstrated, the contribution of lipid micro-environment and more specifically oxysterols is yet to be explored.