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Sex difference in flux of 27‐hydroxycholesterol into the brain
Author(s) -
ParradoFernandez Cristina,
Leoni Valerio,
Saeed Ahmed,
RodriguezRodriguez Patricia,
SandebringMatton Anna,
CórdobaBeldad Carmen M.,
Bueno Paula,
Gali Chaitanya Chakravarthi,
Panzenboeck Ute,
CedazoMinguez Angel,
Björkhem Ingemar
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15353
Subject(s) - flux (metallurgy) , neuroscience , chemistry , biology , organic chemistry
The cerebrospinal fluid (CSF)/plasma albumin ratio (QAlb) is believed to reflect the integrity of the blood-brain barrier (BBB). Recently, we reported that QAlb is lower in females. This may be important for uptake of neurotoxic 27-hydroxycholesterol (27OH) by the brain in particular because plasma levels of 27OH are higher in males. We studied sex differences in the relation between CSF and plasma levels of 27OH and its major metabolite 7α-hydroxy-3-oxo-4-cholestenoic acid (7HOCA) with QAlb. We tested the possibility of sex differences in the brain metabolism of 27OH and if its flux into the brain disrupted integrity of the BBB.