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Adipose tissue is a key organ for the beneficial effects of GLP‐2 metabolic function
Author(s) -
Ejarque Miriam,
SabadellBasallote Joan,
Beiroa Daniel,
Calvo Enrique,
Keiran Noelia,
NuñezRoa Catalina,
Rodríguez Maria del Mar,
Sabench Fatima,
Castillo Daniel,
Jimenez Veronica,
Bosch Fatima,
Nogueiras Ruben,
Vendrell Joan,
FernándezVeledo Sonia
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15278
Subject(s) - adipose tissue , medicine , endocrinology , carbohydrate metabolism , receptor , biology , obesity
Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone released in response to nutritional intake that exerts a wide range of effects by activating GLP-2 receptors. In addition to its intestinotrophic effects, GLP-2 also positively influences glucose metabolism under conditions of obesity, but the mechanisms behind this remain unclear. Here, we have investigated the molecular role of the GLP-2/GLP-2 receptor axis in energetic metabolism, focusing on its potential modulatory effects on adipose tissue.