2‐Hydroxypropyl‐β‐cyclodextrin reduces retinal cholesterol in wild‐type and  Cyp27a1   −/−   Cyp46a1   −/−   mice with deficiency in the oxysterol production | Zendy

ElDarzi Nicole | Zendy; Mast Natalia | Zendy; Petrov Alexey M. | Zendy; Pikuleva Irina A. | Zendy

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2‐Hydroxypropyl‐β‐cyclodextrin reduces retinal cholesterol in wild‐type and Cyp27a1 −/− Cyp46a1 −/− mice with deficiency in the oxysterol production

Author(s) -

ElDarzi Nicole,

Mast Natalia,

Petrov Alexey M.,

Pikuleva Irina A.

Publication year - 2021

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.15209

Subject(s) - oxysterol , cyp27a1 , cholesterol , liver x receptor , retinal , ldl receptor , biology , biochemistry , endocrinology , chemistry , medicine , lipoprotein , nuclear receptor , gene , transcription factor

2-Hydroxypropyl-β-cyclodextrin (HPCD) is an FDA approved vehicle for drug delivery and an efficient cholesterol-lowering agent. HPCD was proposed to lower tissue cholesterol via multiple mechanisms including those mediated by oxysterols. CYP27A1 and CYP46A1 are the major oxysterol-producing enzymes in the retina that convert cholesterol to 27- and 24-hydroxycholesterol, respectively. We investigated whether HPCD treatments affected the retina of wild-type and Cyp27a1 -/- Cyp46a1 -/- mice that do not produce the major retinal oxysterols.

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