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Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis
Author(s) -
Yeh Wei Zhen,
Gresle Melissa,
Jokubaitis Vilija,
Stankovich Jim,
Walt Anneke,
Butzkueven Helmut
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15201
Subject(s) - multiple sclerosis , vitamin d and neurology , immune system , medicine , vitamin d deficiency , disease , vitamin , clinical trial , immunology , demyelinating disease , immunopathology , bone health , autoimmune disease , osteoporosis , bone mineral
Initially recognised as an important factor for bone health, vitamin D is now known to have a range of effects on the immune system. Vitamin D deficiency is associated with an increased risk of multiple sclerosis (MS), a chronic immune‐mediated demyelinating disease of the CNS. In this review, we explore the links between vitamin D deficiency, MS risk, and disease activity. We also discuss the known immune effects of vitamin D supplementation and the relevance of these observations to the immunopathology of MS. Finally, we review the existing evidence for vitamin D supplementation as an MS therapy, highlighting several recent clinical studies and trials.