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Hypoxia‐induced pulmonary hypertension—Utilizing experiments of nature
Author(s) -
Gassmann Max,
Cowburn Andrew,
Gu Hong,
Li Jia,
Rodriguez Marisela,
Babicheva Aleksandra,
Jain Pritesh P.,
Xiong Mingmei,
Gassmann Nori.,
Yuan Jason X.J.,
Wilkins Martin R.,
Zhao Lan
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15144
Subject(s) - hypoxia (environmental) , pulmonary hypertension , blood pressure , cardiology , pulmonary artery , medicine , intensive care medicine , bioinformatics , biology , oxygen , chemistry , organic chemistry
An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on the right ventricle. The mechanisms initiating and maintaining the elevated pressure are of considerable interest in understanding pulmonary vascular homeostasis. There is an expectation that identifying the key molecules in the integrated vascular response to hypoxia will inform potential drug targets. One strategy is to take advantage of experiments of nature, specifically, to understand the genetic basis for the inter-individual variation in the pulmonary vascular response to acute and chronic hypoxia. To date, detailed phenotyping of highlanders has focused on haematocrit and oxygen saturation rather than cardiovascular phenotypes. This review explores what we can learn from those studies with respect to the pulmonary circulation. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.1/issuetoc.