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Possible mechanisms of cancer prevention by nicotinamide
Author(s) -
Buqué Aitziber,
Bloy Norma,
Kroemer Guido,
Galluzzi Lorenzo
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15096
Subject(s) - nicotinamide , carcinogenesis , medicine , cancer , skin cancer , incidence (geometry) , bioinformatics , cancer incidence , dermatology , cancer research , biology , biochemistry , physics , optics , enzyme
Nicotinamide (NAM) is a precursor of vitamin B 3 commonly sold over the counter as a nutritional supplement with anti-aging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. Supporting the translational relevance of dietary NAM supplementation, results from a Phase 3 randomized clinical trial have demonstrated that oral NAM was safe and efficiently reduced the incidence of new non-melanoma skin cancers and actinic keratosis amongst high-risk individuals. However, the molecular and cellular mechanisms that underlie this ability of NAM to delay carcinogenesis remain to be clarified, as discussed in this short review. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.