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Palmitoylethanolamide counteracts brain fog improving depressive‐like behaviour in obese mice: Possible role of synaptic plasticity and neurogenesis
Author(s) -
Lama Adriano,
Pirozzi Claudio,
Annunziata Chiara,
Morgese Maria Grazia,
Senzacqua Martina,
Severi Ilenia,
Calignano Antonio,
Trabace Luigia,
Giordano Antonio,
Meli Rosaria,
Mattace Raso Giuseppina
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15071
Subject(s) - synaptic plasticity , neurochemical , nucleus accumbens , hippocampus , neurogenesis , neuroscience , monoamine neurotransmitter , prefrontal cortex , dopamine , endocrinology , medicine , palmitoylethanolamide , biology , serotonin , agonist , cognition , receptor , cannabinoid receptor
High-fat diet (HFD)-induced obesity is accompanied by metabolic and neurochemical changes that have been associated with depression. Recent studies indicate that palmitoylethanolamide (PEA) exerts metabolic effects and holds neuroprotective potential. However, studies on HFD exposure in mice which investigate the effects of PEA on monoamine system and synaptic plasticity are limited.