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Amelioration of elastase‐induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice
Author(s) -
Fysikopoulos Athanasios,
Seimetz Michael,
Hadzic Stefan,
Knoepp Fenja,
Wu ChengYu,
Malkmus Kathrin,
Wilhelm Jochen,
Pichl Alexandra,
Bednorz Mariola,
Tadele Roxlau Elsa,
Ghofrani Hossein A.,
Sommer Natascha,
Gierhardt Mareike,
Schermuly Ralph T.,
Seeger Werner,
Grimminger Friedrich,
Weissmann Norbert,
Kraut Simone
Publication year - 2021
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15057
Subject(s) - medicine , pulmonary hypertension , lung , elastase , respiratory disease , pulmonary emphysema , copd , pancreatic elastase , pathology , nitric oxide , cardiology , pharmacology , enzyme , biology , biochemistry
Chronic obstructive pulmonary disease, encompassing chronic airway obstruction and lung emphysema, is a major worldwide health problem and a severe socio-economic burden. Evidence previously provided by our group has shown that inhibition of inducible NOS (iNOS) prevents development of mild emphysema in a mouse model of chronic tobacco smoke exposure and can even trigger lung regeneration. Moreover, we could demonstrate that pulmonary hypertension is not only abolished in cigarette smoke-exposed iNOS -/- mice but also precedes emphysema development. Possible regenerative effects of pharmacological iNOS inhibition in more severe models of emphysema not dependent on tobacco smoke, however, are hitherto unknown.