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The constitutive androstane receptor and pregnane X receptor in the brain
Author(s) -
TorresVergara Pablo,
Ho Yu Siong,
Espinoza Francisca,
Nualart Francisco,
Escudero Carlos,
Penny Jeffrey
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15055
Subject(s) - constitutive androstane receptor , pregnane x receptor , pregnane , nuclear receptor , receptor , biology , medicine , endocrinology , pharmacology , transcription factor , biochemistry , genetics , gene
Since their discovery, the orphan nuclear receptors constitutive androstane receptor (CAR;NR1I3) and pregnane X receptor (PXR;NR1I2) have been regarded as master regulators of drug disposition and detoxification mechanisms. They regulate the metabolism and transport of endogenous mediators and xenobiotics in organs including the liver, intestine and brain. However, with proposals of new physiological functions for NR1I3 and NR1I2, there is increasing interest in the role of these receptors in influencing brain function. This review will summarise key findings regarding the expression and function of NR1I3 and NR1I2 in the brain, hereby highlighting the need for further research in this field.