P7C3‐A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP‐activated protein kinase/CREB regulated transcription coactivator 2 pathway | Zendy

Hua Xia | Zendy; Sun DiYang | Zendy; Zhang WenJie | Zendy; Fu JiangTao | Zendy; Tong Jie | Zendy; Sun SiJia | Zendy; Zeng FeiYan | Zendy; Ouyang ShenXi | Zendy; Zhang GuoYan | Zendy; Wang ShuNa | Zendy; Li DongJie | Zendy; Miao ChaoYu | Zendy; Wang Pei | Zendy

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P7C3‐A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP‐activated protein kinase/CREB regulated transcription coactivator 2 pathway

Author(s) -

Hua Xia,

Sun DiYang,

Zhang WenJie,

Fu JiangTao,

Tong Jie,

Sun SiJia,

Zeng FeiYan,

Ouyang ShenXi,

Zhang GuoYan,

Wang ShuNa,

Li DongJie,

Miao ChaoYu,

Wang Pei

Publication year - 2021

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.15008

Subject(s) - creb , amp activated protein kinase , microbiology and biotechnology , transcription factor , chemistry , protein kinase a , biochemistry , biology , kinase , gene , ampk

Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem with no established pharmacological therapy. Here, we explored the potential benefit of P7C3-A20, a novel aminopropyl carbazole compound with neuroprotective activity, in a NAFLD model, induced in mice by a high-fat diet (HFD).

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