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Hyperlipidaemia and cardioprotection: Animal models for translational studies
Author(s) -
Andreadou Ioanna,
Schulz Rainer,
Badimon Lina,
Adameová Adriana,
Kleinbongard Petra,
Lecour Sandrine,
Nikolaou PanagiotaEfstathia,
FalcãoPires Ines,
Vilahur Gemma,
Woudberg Nicholas,
Heusch Gerd,
Ferdinandy Péter
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14931
Subject(s) - cardioprotection , medicine , animal studies , reperfusion injury , translational research , bioinformatics , pharmacology , ischemia , intensive care medicine , biology , pathology
Hyperlipidaemia is a well-established risk factor for cardiovascular diseases and therefore, many animal model have been developed to mimic the human abnormal elevation of blood lipid levels. In parallel, extensive research for the alleviation of ischaemia/reperfusion injury has revealed that hyperlipidaemia is a major co-morbidity that attenuates the cardioprotective effect of conditioning strategies (preconditioning, postconditioning and remote conditioning) and that of pharmacological interventions by interfering with cardioprotective signalling pathways. In the present review article, we summarize the existing data on animal models of hypercholesterolaemia (total, low density and HDL abnormalities) and hypertriglyceridaemia used in ischaemia/reperfusion injury and protection from it. We also provide recommendations on preclinical animal models to be used for translations of the cardioprotective strategies into clinical practice. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc.