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Modulation of the functions of myeloid‐derived suppressor cells : a new strategy of hydrogen sulfide anti‐cancer effects
Author(s) -
De Cicco Paola,
Ercolano Giuseppe,
Rubino Valentina,
Terrazzano Giuseppe,
Ruggiero Giuseppina,
Cirino Giuseppe,
Ianaro Angela
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14824
Subject(s) - melanoma , cancer research , myeloid derived suppressor cell , diallyl trisulfide , cancer , immune system , spleen , immunology , cd8 , cancer cell , cancer immunotherapy , t cell , chemistry , immunotherapy , pharmacology , medicine , suppressor , biochemistry , apoptosis
Myeloid-derived suppressor cells (MDSCs) represent a major obstacle to cancer treatment, as they negatively regulate anti-tumour immunity through the suppression of tumour-specific T lymphocytes. Thus, the efficacy of immunotherapies may be improved by targeting MDSCs. In this study, we assessed the ability of hydrogen sulfide (H 2 S), a gasotransmitter whose anti-cancer effects are well known, to inhibit the accumulation and immunosuppressive functions of MDSCs in melanoma.