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Histamine up‐regulates oncostatin M expression in human M1 macrophages
Author(s) -
Mommert Susanne,
Hüer Marius,
SchaperGerhardt Katrin,
Gutzmer Ralf,
Werfel Thomas
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14796
Subject(s) - oncostatin m , histamine , microbiology and biotechnology , histamine h4 receptor , cytokine , biology , histamine h2 receptor , human skin , chemistry , immunology , receptor , endocrinology , interleukin 6 , biochemistry , genetics , antagonist
Human monocyte-derived M1 macrophages develop in relation to growth factors, bacterial products, and cytokines in a local micro-environment. M1 macrophages produce pro-inflammatory mediators, in particular, oncostatin M (OSM), which is secreted from the cells in response to the active complement component C5a. As C5a also releases histamine from human mast cells and shows immune modulatory functions similar to histamine in regulating expression of the IL-12 cytokine family, we investigated the effects of histamine on OSM expression in human M1 macrophages.