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Anomalous K v 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H 2 S and persulfidation in skeletal muscle
Author(s) -
Vellecco Valentina,
Martelli Alma,
Bibli Iris Sofia,
Vallifuoco Marianna,
Manzo Onorina L.,
Panza Elisabetta,
Citi Valentina,
Calderone Vincenzo,
Dominicis Gianfranco,
Cozzolino Caterina,
Basso Elisabetta M.,
Mariniello Martina,
Fleming Ingrid,
Mancini Antonio,
Bucci Mariarosaria,
Cirino Giuseppe
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14700
Subject(s) - skeletal muscle , malignant hyperthermia , depolarization , medicine , endocrinology , muscle contraction , chemistry , contractility , pathology
Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H 2 S within skeletal muscle. This increase contributes to skeletal muscle hypercontractility. K v 7 channels, expressed in skeletal muscle, may be a molecular target for H 2 S. Here, we have investigated the role of K v 7 channels in MH.