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Histamine, histamine receptors, and neuropathic pain relief
Author(s) -
Obara Ilona,
Telezhkin Vsevolod,
Alrashdi Ibrahim,
Chazot Paul L.
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14696
Subject(s) - histamine , neuropathic pain , histamine receptor , neuroscience , histamine h3 receptor , receptor , medicine , postsynaptic potential , histamine h2 receptor , histamine h4 receptor , pharmacology , psychology , agonist , antagonist
Histamine, acting via distinct histamine H 1 , H 2 , H 3 , and H 4 receptors, regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of H 3 receptor and H 4 receptor in the modulation of neuropathic pain, which remains challenging in terms of management. However, recent data show contrasting effects on neuropathic pain due to multiple factors that determine the pharmacological responses of histamine receptors and their underlying signal transduction properties (e.g., localization on either the presynaptic or postsynaptic neuronal membranes). This review summarizes the most recent findings on the role of histamine and the effects mediated by the four histamine receptors in response to the various stimuli associated with and promoting neuropathic pain. We particularly focus on mechanisms underlying histamine-mediated analgesia, as we aim to clarify the analgesic potential of histamine receptor ligands in neuropathic pain. LINKED ARTICLES: This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/issuetoc.