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Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease
Author(s) -
Sikura Katalin Éva,
Potor László,
Szerafin Tamás,
Oros Melinda,
Nagy Péter,
Méhes Gábor,
Hendrik Zoltán,
Zarjou Abolfazl,
Agarwal Anupam,
Posta Niké,
Torregrossa Roberta,
Whiteman Matthew,
Fürtös Ibolya,
Balla György,
Balla József
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14691
Subject(s) - calcification , osteocalcin , medicine , matrix gla protein , aortic valve stenosis , aorta , endocrinology , aortic valve , chemistry , alkaline phosphatase , ectopic calcification , biochemistry , enzyme
Calcification of heart valves is a frequent pathological finding in chronic kidney disease and in elderly patients. Hydrogen sulfide (H 2 S) may exert anti-calcific actions. Here we investigated H 2 S as an inhibitor of valvular calcification and to identify its targets in the pathogenesis.