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Discovery of early life stress interacting and sex‐specific quantitative trait loci impacting cocaine responsiveness
Author(s) -
Bagley Jared R.,
Szumlinski Karen K.,
Kippin Tod E.
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14661
Subject(s) - quantitative trait locus , offspring , biology , genetics , phenotype , gene , conditioned place preference , candidate gene , addiction , neuroscience , pregnancy
Addiction vulnerability involves complex gene X environment interactions leading to a pathological response to drugs. Identification of the genes involved in these interactions is an important step in understanding the underlying neurobiology and rarely have such analyses examined sex-specific influences. To dissect this interaction, we examined the impact of prenatal stress (PNS) on cocaine responsiveness in male and female mice of the BXD recombinant inbred panel.