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β 3 ‐Adrenoceptor as a potential immuno‐suppressor agent in melanoma
Author(s) -
Calvani Maura,
Bruno Gennaro,
Dal Monte Massimo,
Nassini Romina,
Fontani Filippo,
Casini Arianna,
Cavallini Lorenzo,
Becatti Matteo,
Bianchini Francesca,
De Logu Francesco,
Forni Giulia,
Marca Giancarlo,
Calorini Lido,
Bagnoli Paola,
Chiarugi Paola,
Pupi Alberto,
Azzari Chiara,
Geppetti Pierangelo,
Favre Claudio,
Filippi Luca
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14660
Subject(s) - immune system , melanoma , cd8 , immunology , cancer research , population , biology , cytotoxic t cell , pharmacology , medicine , biochemistry , environmental health , in vitro
Stress-related catecholamines have a role in cancer and β-adrenoceptors; specifically, β 2 -adrenoceptors have been identified as new targets in treating melanoma. Recently, β 3 -adrenoceptors have shown a pleiotropic effect on melanoma micro-environment leading to cancer progression. However, the mechanisms by which β 3 -adrenoceptors promote this progression remain poorly understood. Catecholamines affect the immune system by modulating several factors that can alter immune cell sub-population homeostasis. Understanding the mechanisms of cancer immune-tolerance is one of the most intriguing challenges in modern research. This study investigates the potential role of β 3 -adrenoceptors in immune-tolerance regulation.