L‐cysteine/cystathionine‐β‐synthase‐induced relaxation in mouse aorta involves a L‐serine/sphingosine‐1‐phosphate/NO pathway | Zendy

Mitidieri Emma | Zendy; Gurgone Danila | Zendy; Caiazzo Elisabetta | Zendy; Tramontano Teresa | Zendy; Cicala Carla | Zendy; Sorrentino Raffaella | Zendy; d'Emmanuele di Villa Bianca Roberta | Zendy

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L‐cysteine/cystathionine‐β‐synthase‐induced relaxation in mouse aorta involves a L‐serine/sphingosine‐1‐phosphate/NO pathway

Author(s) -

Mitidieri Emma,

Gurgone Danila,

Caiazzo Elisabetta,

Tramontano Teresa,

Cicala Carla,

Sorrentino Raffaella,

d'Emmanuele di Villa Bianca Roberta

Publication year - 2020

Publication title -

british journal of pharmacology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.14654

Subject(s) - serine , cystathionine beta synthase , cysteine , biochemistry , chemistry , cystathionine gamma lyase , phosphorylation , enzyme

Among the three enzymes involved in the transsulfuration pathway, only cystathionine β-synthase (CBS) converts L-cysteine into L-serine and H 2 S. L-serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl-CoA by the action of serine palmitoyltransferase (SPT). Here, we have investigated if L-serine contributes to the vasorelaxant effect.

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