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Erucin exhibits vasorelaxing effects and antihypertensive activity by H 2 S‐releasing properties
Author(s) -
Martelli Alma,
Piragine Eugenia,
Citi Valentina,
Testai Lara,
Pagnotta Eleonora,
Ugolini Luisa,
Lazzeri Luca,
Di Cesare Mannelli Lorenzo,
Manzo Onorina Laura,
Bucci Mariarosaria,
Ghelardini Carla,
Breschi Maria Cristina,
Calderone Vincenzo
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14645
Subject(s) - vasodilation , vasoconstriction , pharmacology , in vivo , vascular smooth muscle , chemistry , endothelium , medicine , biology , smooth muscle , microbiology and biotechnology
Hydrogen sulfide (H 2 S)-releasing agents are viewed as potential antihypertensive drugs. Recently, natural isothiocyanates emerged as original H 2 S-donor agents. Among them, erucin, present in some edible cruciferous plants, shows suitable H 2 S-releasing properties and features of "druggability." The aim of this work was to investigate the erucin-mediated release of H 2 S inside vascular cells, its vasorelaxing effects, and activity on BP of normo and hypertensive animals.