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Histamine in the kidneys: what is its role in renal pathophysiology?
Author(s) -
Grange Cristina,
Gurrieri Maura,
Verta Roberta,
Fantozzi Roberto,
Pini Alessandro,
Rosa Arianna Carolina
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14619
Subject(s) - histamine receptor , histamine , kidney , renal physiology , histaminergic , histamine h3 receptor , receptor , pathophysiology , renal blood flow , biology , endocrinology , medicine , neuroscience , antagonist
Starting with a role for histamine role in renal haemodynamics, evidence has accumulated, over time, suggesting a wider range of actions on renal function and this has renewed interest in the pathophysiological role of histamine in the kidney. Here we provide an up-to-date review of this topic. As the kidney expresses enzymes that synthesize and metabolise histamine, along with its receptors, all the components for histaminergic transmission are present in this tissue. The distribution of histamine receptors matches a wide range of effects. We address the questions of the redundancy of H 1 and H 2 receptors in renal haemodynamics, the complementary role of H 1 and H 4 receptors in renal filtration and reabsorption, and the dichotomy between local and neuronal H 1 and H 3 receptors. Experimental models of renal disease raise the possibility of new therapeutic approaches based on histamine. The effects of histamine on renal function are not yet fully understood and their elucidation is still ongoing. LINKED ARTICLES: This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/issuetoc.