Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys 44  to prevent cardiac structural damage in diabetic cardiomyopathy | Zendy

Sun Xiaojiao | Zendy; Zhao Dechao | Zendy; Lu Fangping | Zendy; Peng Shuo | Zendy; Yu Miao | Zendy; Liu Ning | Zendy; Sun Yu | Zendy; Du Haining | Zendy; Wang Bingzhu | Zendy; Chen Jian | Zendy; Dong Shiyun | Zendy; Lu Fanghao | Zendy; Zhang Weihua | Zendy

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Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys 44 to prevent cardiac structural damage in diabetic cardiomyopathy

Author(s) -

Sun Xiaojiao,

Zhao Dechao,

Lu Fangping,

Peng Shuo,

Yu Miao,

Liu Ning,

Sun Yu,

Du Haining,

Wang Bingzhu,

Chen Jian,

Dong Shiyun,

Lu Fanghao,

Zhang Weihua

Publication year - 2020

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.14601

Subject(s) - hydrogen sulfide , cardiomyopathy , diabetic cardiomyopathy , cardiac muscle , mitochondrion , sulfide , chemistry , muscle protein , medicine , biochemistry , heart failure , sulfur , skeletal muscle , organic chemistry

Hydrogen sulfide (H 2 S) plays important roles as a gasotransmitter in pathologies. Increased expression of the E3 ubiquitin ligase, muscle RING finger-1 (MuRF1), may be involved in diabetic cardiomyopathy. Here we have investigated whether and how exogenous H 2 S alleviates cardiac muscle degradation through modifications of MuRF1 S-sulfhydration in db/db mice.

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