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Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear–safety discrimination
Author(s) -
Clark Jacob W.,
Drummond Sean P.A.,
Hoyer Daniel,
Jacobson Laura H.
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14600
Subject(s) - fear conditioning , extinction (optical mineralogy) , psychology , safety behaviors , recall , developmental psychology , freezing behavior , audiology , injury prevention , poison control , medicine , anxiety , psychiatry , cognitive psychology , biology , paleontology , environmental health
Women are overrepresented in post-traumatic stress disorder (PTSD), a mental disorder characterised by ineffective inhibition of fear. The use of male animals dominates preclinical studies, which may contribute to a lack of understanding as to why this disparity exists. Thus, the current study explores sex differences in three mouse models of fear inhibition.