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Neutralization of IL‐17 rescues amyloid‐β‐induced neuroinflammation and memory impairment
Author(s) -
Cristiano Claudia,
Volpicelli Floriana,
Lippiello Pellegrino,
Buono Benedetta,
Raucci Federica,
Piccolo Marialuisa,
Iqbal Asif Jilani,
Irace Carlo,
Miniaci Maria Concetta,
Perrone Capano Carla,
Calignano Antonio,
Mascolo Nicola,
Maione Francesco
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14586
Subject(s) - neuroinflammation , neurodegeneration , proinflammatory cytokine , medicine , alzheimer's disease , cytokine , memory impairment , neuroscience , pharmacology , immunology , inflammation , disease , psychology , psychiatry , cognition
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by a neuroinflammatory state, and to date, there is no cure and its treatment represents a large unmet clinical need. The involvement of Th17 cells in the pathogenesis of AD-related neuroinflammation has been reported in several studies. However, the role of the cytokine, IL-17 has not been well addressed. Herein, we investigate the effects of IL-17 neutralizing antibody (IL-17Ab) injected by i.c.v. or intranasal (IN) routes on amyloid-β (Aβ)-induced neuroinflammation and memory impairment in mice.