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Preclinical evaluation of [ 18 F]MA3: a CB 2 receptor agonist radiotracer for PET
Author(s) -
Attili Bala,
Celen Sofie,
Ahamed Muneer,
Koole Michel,
Haute Chris Van Den,
Vanduffel Wim,
Bormans Guy
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14564
Subject(s) - receptor , agonist , chemistry , in vivo , inverse agonist , striatum , receptor expression , pharmacology , biochemistry , endocrinology , biology , dopamine , microbiology and biotechnology
Non-invasive in vivo imaging of cannabinoid CB 2 receptors using PET is pursued to study neuroinflammation. The purpose of this study is to evaluate the in vivo binding specificity of [ 18 F]MA3, a CB 2 receptor agonist, in a rat model with local overexpression of human (h) CB 2 receptors.
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