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Hydrogen sulfide and hepatic lipid metabolism – a critical pairing for liver health
Author(s) -
Loiselle Julie J,
Yang Guangdong,
Wu Lingyun
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14556
Subject(s) - lipid metabolism , hydrogen sulfide , liver disease , biology , medicine , chemistry , bioinformatics , biochemistry , sulfur , organic chemistry
Hydrogen sulfide (H 2 S) is the most recently recognized gasotransmitter, influencing a wide range of physiological processes. As a critical regulator of metabolism, H 2 S has been suggested to be involved in the pathology of many diseases, particularly obesity, diabetes and cardiovascular disorders. Its involvement in liver health has been brought to light more recently, particularly through knockout animal models, which show severe hepatic lipid accumulation upon ablation of H 2 S metabolic pathways. A complex relationship between H 2 S and lipid metabolism in the liver is emerging, which has significant implications for liver disease establishment and/or progression, regardless of the disease-causing agent. In this review, we discuss the critical importance of H 2 S in hepatic lipid metabolism. We then describe the animal models so far related with H 2 S and lipid-associated liver disease, as well as H 2 S-based treatments available. Finally, we highlight important considerations for future studies and identify areas in which much still remains to be determined. LINKED ARTICLES: This article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc.