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Mitochondrial depolarization stimulates vascular repair‐relevant functions of CD34 + cells via reactive oxygen species‐induced nitric oxide generation
Author(s) -
Joshi Shrinidh,
Jarajapu Yagna P R
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14529
Subject(s) - diazoxide , microbiology and biotechnology , chemistry , biology , mitochondrion , enos , nitric oxide , pharmacology , medicine , endocrinology , nitric oxide synthase , insulin
CD34 + haematopoietic stem/progenitor cells have revascularization potential and are now being tested for the treatment of ischaemic vascular diseases in clinical trials. We tested the hypothesis that mitochondrial depolarization stimulates the reparative functions of CD34 + cells.