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Mitochondrial function in the heart: the insight into mechanisms and therapeutic potentials
Author(s) -
Nguyen Binh Yen,
RuizVelasco Andrea,
Bui Thuy,
Collins Lucy,
Wang Xin,
Liu Wei
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14431
Subject(s) - mitochondrion , mitochondrial disease , disease , biology , mitochondrial dna , translation (biology) , bioinformatics , mitochondrial fusion , neuroscience , function (biology) , pharmacology , microbiology and biotechnology , medicine , computational biology , genetics , pathology , messenger rna , gene
Mitochondrial dysfunction is considered as a crucial contributory factor in cardiac pathology. This has highlighted the therapeutic potential of targeting mitochondria to prevent or treat cardiac disease. Mitochondrial dysfunction is associated with aberrant electron transport chain activity, reduced ATP production, an abnormal shift in metabolic substrates, ROS overproduction and impaired mitochondrial dynamics. This review will cover the mitochondrial functions and how they are altered in various disease conditions. Furthermore, the mechanisms that lead to mitochondrial defects and the protective mechanisms that prevent mitochondrial damage will be discussed. Finally, potential mitochondrial targets for novel therapeutic intervention will be explored. We will highlight the development of small molecules that target mitochondria from different perspectives and their current progress in clinical trials. LINKED ARTICLES: This article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.22/issuetoc.