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In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP‐505
Author(s) -
Dietis N,
Niwa H,
Tose R,
McDonald J,
Ruggieri V,
Filaferro M,
Vitale G,
Micheli L,
Ghelardini C,
Salvadori S,
Calo G,
Guerrini R,
Rowbotham D J,
Lambert D G
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14199
Subject(s) - agonist , receptor , pharmacology , opioid , morphine , chemistry , opioid receptor , in vivo , medicine , biology , biochemistry , microbiology and biotechnology
Targeting more than one opioid receptor type simultaneously may have analgesic advantages in reducing side-effects. We have evaluated the mixed μ opioid receptor agonist/ δ opioid receptor antagonist UFP-505 in vitro and in vivo.