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Human secreted proteins SLURP‐1 and SLURP‐2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors
Author(s) -
Lyukmanova E N,
Bychkov M L,
Sharonov G V,
Efremenko A V,
Shulepko M A,
Kulbatskii D S,
Shenkarev Z O,
Feofanov A V,
Dolgikh D A,
Kirpichnikov M P
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14194
Subject(s) - a431 cells , nicotinic agonist , skbr3 , receptor , cell growth , cancer cell , epidermal growth factor , microbiology and biotechnology , chemistry , biology , biochemistry , medicine , cancer , cell , cell cycle , oncogene , human breast
Nicotinic acetylcholine receptors (nAChRs) are a promising target for development of new anticancer therapies. Here we have investigated the effects of the endogenous human proteins SLURP-1 and SLURP-2, antagonists of nAChRs, on human epithelial cancer cells.