Single and combined effects of plant‐derived and synthetic cannabinoids on cognition and cannabinoid‐associated withdrawal signs in mice | Zendy

Myers Alyssa M | Zendy; Siegele Patrick B | Zendy; Foss Jeffrey D | Zendy; Tuma Ronald F | Zendy; Ward Sara Jane | Zendy

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Single and combined effects of plant‐derived and synthetic cannabinoids on cognition and cannabinoid‐associated withdrawal signs in mice

Author(s) -

Myers Alyssa M,

Siegele Patrick B,

Foss Jeffrey D,

Tuma Ronald F,

Ward Sara Jane

Publication year - 2019

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.14147

Subject(s) - cannabidiol , cannabinoid receptor , rimonabant , cannabinoid , pharmacology , antagonist , agonist , partial agonist , medicine , cannabinoid receptor antagonist , tetrahydrocannabinol , receptor antagonist , endocannabinoid system , cannabinoid receptor type 2 , receptor , cannabis , psychiatry

It has been suggested that the non-euphorogenic phytocannabinoid cannabidiol (CBD) can ameliorate adverse effects of Δ 9 -tetrahydrocannabinol (THC). We determined whether CBD ameliorates cognitive deficits and withdrawal signs induced by cannabinoid CB 1 /CB 2 receptor agonists or produces these pharmacological effects on its own.

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