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Inhibition of acid‐sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain
Author(s) -
Lee Jia Yu Peppermint,
Saez Natalie J,
CristoforiArmstrong Ben,
Anangi Raveendra,
King Glenn F,
Smith Maree T,
Rash Lachlan D
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14089
Subject(s) - pharmacology , acid sensing ion channel , in vivo , analgesic , chemistry , morphine , medicine , ion channel , biology , biochemistry , receptor , microbiology and biotechnology
Acid-sensing ion channels (ASICs) are primary acid sensors in mammals, with the ASIC1b and ASIC3 subtypes being involved in peripheral nociception. The antiprotozoal drug diminazene is a moderately potent ASIC inhibitor, but its analgesic activity has not been assessed.