Inhibition of acid‐sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain | Zendy

Lee Jia Yu Peppermint | Zendy; Saez Natalie J | Zendy; CristoforiArmstrong Ben | Zendy; Anangi Raveendra | Zendy; King Glenn F | Zendy; Smith Maree T | Zendy; Rash Lachlan D | Zendy

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Inhibition of acid‐sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

Author(s) -

Lee Jia Yu Peppermint,

Saez Natalie J,

CristoforiArmstrong Ben,

Anangi Raveendra,

King Glenn F,

Smith Maree T,

Rash Lachlan D

Publication year - 2018

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.14089

Subject(s) - pharmacology , acid sensing ion channel , in vivo , analgesic , chemistry , morphine , medicine , ion channel , biology , biochemistry , receptor , microbiology and biotechnology

Acid-sensing ion channels (ASICs) are primary acid sensors in mammals, with the ASIC1b and ASIC3 subtypes being involved in peripheral nociception. The antiprotozoal drug diminazene is a moderately potent ASIC inhibitor, but its analgesic activity has not been assessed.

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