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Wheel running during chronic nicotine exposure is protective against mecamylamine‐precipitated withdrawal and up‐regulates hippocampal α7 nACh receptors in mice
Author(s) -
Keyworth Helen,
Georgiou Polymnia,
Zanos Panos,
Rueda André Veloso,
Chen Ying,
Kitchen Ian,
Camarini Rosana,
Cropley Mark,
Bailey Alexis
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14068
Subject(s) - nicotine , mecamylamine , nicotine withdrawal , endocrinology , brain derived neurotrophic factor , medicine , kindling , nicotinic agonist , corticosterone , hippocampal formation , receptor , neurotrophic factors , hippocampus , pharmacology , chemistry , stimulation , hormone
Evidence suggests that exercise decreases nicotine withdrawal symptoms in humans; however, the mechanisms mediating this effect are unclear. We investigated, in a mouse model, the effect of exercise intensity during chronic nicotine exposure on nicotine withdrawal severity, binding of α4β2*, α7 nicotinic acetylcholine (nAChR), μ-opioid (μ receptors) and D 2 dopamine receptors and on brain-derived neurotrophic factor (BDNF) and plasma corticosterone levels.