Wheel running during chronic nicotine exposure is protective against mecamylamine‐precipitated withdrawal and up‐regulates hippocampal α7 nACh receptors in mice | Zendy

Keyworth Helen | Zendy; Georgiou Polymnia | Zendy; Zanos Panos | Zendy; Rueda André Veloso | Zendy; Chen Ying | Zendy; Kitchen Ian | Zendy; Camarini Rosana | Zendy; Cropley Mark | Zendy; Bailey Alexis | Zendy

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Wheel running during chronic nicotine exposure is protective against mecamylamine‐precipitated withdrawal and up‐regulates hippocampal α7 nACh receptors in mice

Author(s) -

Keyworth Helen,

Georgiou Polymnia,

Zanos Panos,

Rueda André Veloso,

Chen Ying,

Kitchen Ian,

Camarini Rosana,

Cropley Mark,

Bailey Alexis

Publication year - 2018

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.14068

Subject(s) - nicotine , mecamylamine , nicotine withdrawal , endocrinology , brain derived neurotrophic factor , medicine , kindling , nicotinic agonist , corticosterone , hippocampal formation , receptor , neurotrophic factors , hippocampus , pharmacology , chemistry , stimulation , hormone

Evidence suggests that exercise decreases nicotine withdrawal symptoms in humans; however, the mechanisms mediating this effect are unclear. We investigated, in a mouse model, the effect of exercise intensity during chronic nicotine exposure on nicotine withdrawal severity, binding of α4β2*, α7 nicotinic acetylcholine (nAChR), μ-opioid (μ receptors) and D 2 dopamine receptors and on brain-derived neurotrophic factor (BDNF) and plasma corticosterone levels.

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