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Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells
Author(s) -
Song Lin,
Ding Sha,
Ge Zhen,
Zhu Xiaolong,
Qiu Cong,
Wang Yuewen,
Lai Enyin,
Yang Weijun,
Sun Yi,
Chow Samson A,
Yu Luyang
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14036
Subject(s) - lymphangiogenesis , angiogenesis , biology , microbiology and biotechnology , cancer research , pharmacology , cancer , metastasis , genetics
Cardiovascular disease associated with antiretroviral therapy (ART) has become a major clinical challenge for HIV-positive patients. However, the role of ART in blood vessel growth is largely unknown. Here, we examined an integral component of ART, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and investigated their effects on key microvascular functions, including angiogenesis and lymphangiogenesis.