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M‐type K + channels in peripheral nociceptive pathways
Author(s) -
Du Xiaona,
Gao Haixia,
Jaffe David,
Zhang Hailin,
Gamper Nikita
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - Slovenian
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13978
Subject(s) - neuroscience , ion channel , analgesic , nociception , chronic pain , somatosensory system , medicine , bioinformatics , pharmacology , biology , receptor
Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and controlled by a complement of ion channels it expresses, in order to understand and treat pain, we need to develop a mechanistic insight into the key ion channels controlling excitability within the mammalian pain pathways and how these ion channels are regulated and modulated in various physiological and pathophysiological settings. In this review, we will discuss the emerging data on the expression in pain pathways, functional role and modulation of a family of voltage-gated K + channels called 'M channels' (KCNQ, K v 7). M channels are increasingly recognized as important players in controlling pain signalling, especially within the peripheral somatosensory system. We will also discuss the therapeutic potential of M channels as analgesic drug targets.