Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis | Zendy

Liu Yajin | Zendy; Fang Xuan | Zendy; Zhang Xu | Zendy; Huang Jing | Zendy; He Jinlong | Zendy; Peng Liyuan | Zendy; Ye Chenji | Zendy; Wang Yingmei | Zendy; Xue Fengxia | Zendy; Ai Ding | Zendy; Li Dan | Zendy; Zhu Yi | Zendy

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Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis

Author(s) -

Liu Yajin,

Fang Xuan,

Zhang Xu,

Huang Jing,

He Jinlong,

Peng Liyuan,

Ye Chenji,

Wang Yingmei,

Xue Fengxia,

Ai Ding,

Li Dan,

Zhu Yi

Publication year - 2018

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13971

Subject(s) - eicosapentaenoic acid , profiling (computer programming) , chemistry , endothelium , pharmacology , biochemistry , biology , fatty acid , endocrinology , polyunsaturated fatty acid , computer science , operating system

Atherosclerosis results from a maladaptive inflammatory response initiated by the intramural retention of LDL in susceptible areas of the arterial vasculature. The ω-3 polyunsaturated fatty acids (ω-3) have protective effects in atherosclerosis; however, their molecular mechanism is still largely unknown. The present study used a metabolomic approach to reveal the atheroprotective metabolites of ω-3 and investigate the underlying mechanisms.

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