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Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis
Author(s) -
Liu Yajin,
Fang Xuan,
Zhang Xu,
Huang Jing,
He Jinlong,
Peng Liyuan,
Ye Chenji,
Wang Yingmei,
Xue Fengxia,
Ai Ding,
Li Dan,
Zhu Yi
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13971
Subject(s) - eicosapentaenoic acid , ldl receptor , inflammation , chemistry , endothelial activation , cytochrome p450 , polyunsaturated fatty acid , monocyte , receptor , medicine , biochemistry , pharmacology , lipoprotein , endocrinology , fatty acid , biology , cholesterol , metabolism
Atherosclerosis results from a maladaptive inflammatory response initiated by the intramural retention of LDL in susceptible areas of the arterial vasculature. The ω-3 polyunsaturated fatty acids (ω-3) have protective effects in atherosclerosis; however, their molecular mechanism is still largely unknown. The present study used a metabolomic approach to reveal the atheroprotective metabolites of ω-3 and investigate the underlying mechanisms.